Gene information
Official symbol PCSK9
Official full name proprotein convertase subtilisin/kexin type 9
Gene type protein-coding gene
Chromosome1p32.3
Alias symbolNARC-1; FH3
Previous symbolHCHOLA3
Gene familyProprotein convertase subtilisin/kexin family
Resources
Entrez Gene 255738
HGNC HGNC:20001
Ensembl ENSG00000169174
Vega OTTHUMG00000008136
UCSC uc001cyf.3
GO terms: 72 records
GO Description Category LogP Number of genes Detail
GO:0000323 lytic vacuole GO Cellular Components -7.25784656 30 More
GO:0001655 urogenital system development GO Biological Processes -19.5104956 58 More
GO:0001822 kidney development GO Biological Processes -16.2664835 49 More
GO:0005764 lysosome GO Cellular Components -7.25784656 30 More
GO:0009267 cellular response to starvation GO Biological Processes -4.23113258 19 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0009896 positive regulation of catabolic process GO Biological Processes -13.5088608 63 More
GO:0009897 external side of plasma membrane GO Cellular Components -28.0033937 46 More
GO:0009991 response to extracellular stimulus GO Biological Processes -42.2178323 102 More
GO:0010469 regulation of signaling receptor activity GO Biological Processes -13.5880476 20 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0010959 regulation of metal ion transport GO Biological Processes -23.6318171 71 More
GO:0010984 regulation of lipoprotein particle clearance GO Biological Processes -13.0318362 16 More
GO:0010985 negative regulation of lipoprotein particle clearance GO Biological Processes -8.96527714 10 More
GO:0010988 regulation of low-density lipoprotein particle clearance GO Biological Processes -8.17037988 10 More
GO:0010989 negative regulation of low-density lipoprotein particle clearance GO Biological Processes -8.80074885 9 More
GO:0022898 regulation of transmembrane transporter activity GO Biological Processes -11.1988499 41 More
GO:0030100 regulation of endocytosis GO Biological Processes -14.0757782 22 More
GO:0030163 protein catabolic process GO Biological Processes -2.20136577 18 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0031667 response to nutrient levels GO Biological Processes -41.8130555 98 More
GO:0031668 cellular response to extracellular stimulus GO Biological Processes -10.2327580 36 More
GO:0031669 cellular response to nutrient levels GO Biological Processes -9.42886914 32 More
GO:0032368 regulation of lipid transport GO Biological Processes -34.5766289 54 More
GO:0032369 negative regulation of lipid transport GO Biological Processes -16.5715041 21 More
GO:0032371 regulation of sterol transport GO Biological Processes -19.2332049 29 More
GO:0032372 negative regulation of sterol transport GO Biological Processes -11.6691020 14 More
GO:0032374 regulation of cholesterol transport GO Biological Processes -19.2332049 29 More
GO:0032375 negative regulation of cholesterol transport GO Biological Processes -11.6691020 14 More
GO:0032409 regulation of transporter activity GO Biological Processes -16.9480646 53 More
GO:0032412 regulation of ion transmembrane transporter activity GO Biological Processes -9.90560995 38 More
GO:0032868 response to insulin GO Biological Processes -11.6850377 35 More
GO:0032869 cellular response to insulin stimulus GO Biological Processes -9.16399556 26 More
GO:0032870 cellular response to hormone stimulus GO Biological Processes -24.7707938 79 More
GO:0034762 regulation of transmembrane transport GO Biological Processes -31.7284805 100 More
GO:0034763 negative regulation of transmembrane transport GO Biological Processes -22.14661 42 More
GO:0034765 regulation of ion transmembrane transport GO Biological Processes -18.4305966 71 More
GO:0042594 response to starvation GO Biological Processes -5.43370462 24 More
GO:0042632 cholesterol homeostasis GO Biological Processes -21.5492593 34 More
GO:0043065 positive regulation of apoptotic process GO Biological Processes -46.1285536 112 More
GO:0043068 positive regulation of programmed cell death GO Biological Processes -46.5713594 114 More
GO:0043269 regulation of ion transport GO Biological Processes -36.9814668 116 More
GO:0043271 negative regulation of ion transport GO Biological Processes -19.3914052 40 More
GO:0043434 response to peptide hormone GO Biological Processes -26.1739008 69 More
GO:0043523 regulation of neuron apoptotic process GO Biological Processes -14.5388618 39 More
GO:0043525 positive regulation of neuron apoptotic process GO Biological Processes -3.54364153 9 More
GO:0043621 protein self-association GO Molecular Functions -3.87198258 11 More
GO:0045806 negative regulation of endocytosis GO Biological Processes -6.50553130 8 More
GO:0048259 regulation of receptor-mediated endocytosis GO Biological Processes -11.3903749 15 More
GO:0048261 negative regulation of receptor-mediated endocytosis GO Biological Processes -5.41560423 6 More
GO:0048471 perinuclear region of cytoplasm GO Cellular Components -8.50169248 66 More
GO:0048732 gland development GO Biological Processes -26.3979320 74 More
GO:0051051 negative regulation of transport GO Biological Processes -46.8709407 107 More
GO:0051098 regulation of binding GO Biological Processes -15.8856010 30 More
GO:0051100 negative regulation of binding GO Biological Processes -8.85516089 15 More
GO:0051129 negative regulation of cellular component organization GO Biological Processes -13.1016989 75 More
GO:0055088 lipid homeostasis GO Biological Processes -20.8046481 43 More
GO:0055092 sterol homeostasis GO Biological Processes -21.3864243 34 More
GO:0060341 regulation of cellular localization GO Biological Processes -10.5933083 72 More
GO:0060627 regulation of vesicle-mediated transport GO Biological Processes -25.1756709 46 More
GO:0071375 cellular response to peptide hormone stimulus GO Biological Processes -15.9961580 44 More
GO:0071417 cellular response to organonitrogen compound GO Biological Processes -26.3253267 90 More
GO:0071496 cellular response to external stimulus GO Biological Processes -17.0078490 52 More
GO:0072001 renal system development GO Biological Processes -17.7796243 52 More
GO:0098552 side of membrane GO Cellular Components -22.4625650 48 More
GO:1901652 response to peptide GO Biological Processes -34.9047734 89 More
GO:1901653 cellular response to peptide GO Biological Processes -21.5212108 58 More
GO:1901699 cellular response to nitrogen compound GO Biological Processes -26.9091664 96 More
GO:1904062 regulation of cation transmembrane transport GO Biological Processes -18.6629834 61 More
GO:1905598 negative regulation of low-density lipoprotein receptor activity GO Biological Processes -6.17980212 4 More
GO:1905952 regulation of lipid localization GO Biological Processes -40.6150331 64 More
GO:1905953 negative regulation of lipid localization GO Biological Processes -25.1573575 31 More
Drug-Gene interaction
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Related drugs: 6 records
Related studies: 11 records
Molecular factor Omics type Application Objective MI type Reference
NM_174936.4:c.94G>A genomics myocardial infarction[diagnosis] myocardial infarction Tajima T et al. Sci Rep. 2018
NC_000001.11:g.[55039995C>G;55039974G>A;55038977G>A;55030366T>C] genomics myocardial infarction[diagnosis] myocardial infarction Schmidt AF et al. BMC Cardiovasc Disord. 2019
proprotein convertase subtilisin/kexin type 9 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Almontashiri NA et al. PLoS One. 2014
proprotein convertase subtilisin/kexin type 9 proteomics acute non-ST elevation myocardial infarction[diagnosis] acute non-ST elevation myocardial infarction Ueland T et al. Open Heart. 2018
proprotein convertase subtilisin/kexin type 9 proteomics hypercholesterolemia[prognosis (bad)] acute non-ST elevation myocardial infarction Ueland T et al. Open Heart. 2018
proprotein convertase subtilisin/kexin type 9 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Zhang Z et al. Sci Rep. 2019
proprotein convertase subtilisin/kexin type 9 proteomics medium predictor coronary artery disease[prognosis (bad)] non-ST elevation myocardial infarction Dalgic Y et al. Coron Artery Dis. 2020
proprotein convertase subtilisin/kexin type 9 proteomics left ventricular ejection fraction[other] acute ST elevation myocardial infarction Minana G et al. ESC Heart Fail. 2020
proprotein convertase subtilisin/kexin type 9 proteomics evolocumab[treatment (pharmacotherapy)] acute myocardial infarction Nakamura A et al. J Cardiol. 2020
NC_000001.11:g.55030366T>C genomics myocardial infarction[diagnosis] myocardial infarction Yu Z et al. Am J Clin Nutr. 2017
NM_174936.4:c.137G>A genomics myocardial infarction[diagnosis] myocardial infarction Ai-Ghalayini KW et al. Heart Surg Forum. 2020
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